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pentobarbital will reduce the extent or impact of copyright topical by affecting hepatic enzyme CYP2B6 metabolism. Insignificant/Significance Unknown.pentobarbital will lower the level or result of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with solid CYP3A4 inducers just isn't prop